WebInfection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (Arm) induces an acute infection with rapid virus clearance by CD8+T cells … WebIn inbred mice, lymphocytic choriomeningitis virus (LCMV) infection elicits robust and typical T cell-dependent B cell responses, including germinal center reaction, memory B cell …
Continuous recruitment of naive T cells contributes to heterogeneity of ...
WebThese mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. WebExperiment Overall Design: Mice containing transferred P14 CD8+ transgenic T cells were infected with LCMV or influenza and rested for 90 days. P14 cells were purified by cell … mylearning thomson reuters
The LCMV gp33-specific memory T cell repertoire narrows with age
Web3 jun. 2024 · We further characterized this early branch point by carrying out single-cell analysis of CD8 T cell populations in the context of acute and chronic lymphocytic choriomeningitis virus (LCMV) infection and observed a TCF1+ progenitor-like population resembling the memory precursor effector cell (MPEC) population in acute infection. Web7 sep. 2024 · Virus-specific PD1 + Tcf1 + memory-like CD8 + T cells (T ML s) maintain the CD8 + T cell response during chronic viral infection. However, the fate of these cells following cessation of persistent antigen exposure has been unclear. Here, we find that T ML s persist upon transfer into antigen-free hosts and form memory following recall … Web5 jan. 2024 · LCMV Armstrong infections in adult mice result in a fully functional and efficient T cell response that clears virus in approximately one week. Alternatively, the … mylearning ti